1szw: Difference between revisions
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New page: left|200px<br /><applet load="1szw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1szw, resolution 2.00Å" /> '''Crystal structure of... |
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[[Image:1szw.gif|left|200px]]<br /><applet load="1szw" size=" | [[Image:1szw.gif|left|200px]]<br /><applet load="1szw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1szw, resolution 2.00Å" /> | caption="1szw, resolution 2.00Å" /> | ||
'''Crystal structure of E. coli tRNA pseudouridine synthase TruD'''<br /> | '''Crystal structure of E. coli tRNA pseudouridine synthase TruD'''<br /> | ||
==Overview== | ==Overview== | ||
Pseudouridine synthases catalyse the isomerisation of uridine to | Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all kingdoms of life. We report here the crystal structure of Escherichia coli TruD at 2.0 A resolution. The structure reveals an overall V-shaped molecule with an RNA-binding cleft formed between two domains: a catalytic domain and an insertion domain. The catalytic domain has a fold similar to that of the catalytic domains of previously characterised pseudouridine synthases, whereas the insertion domain displays a novel fold. | ||
==About this Structure== | ==About this Structure== | ||
1SZW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] Full crystallographic information is available from [http:// | 1SZW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Pseudouridylate synthase]] | [[Category: Pseudouridylate synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ericsson, U | [[Category: Ericsson, U B.]] | ||
[[Category: Hallberg, B | [[Category: Hallberg, B M.]] | ||
[[Category: Nordlund, P.]] | [[Category: Nordlund, P.]] | ||
[[Category: SPINE, Structural | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
[[Category: novel fold]] | [[Category: novel fold]] | ||
[[Category: pseudouridine synthase]] | [[Category: pseudouridine synthase]] | ||
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[[Category: trud]] | [[Category: trud]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:08:07 2008'' | ||
