Sandbox Reserved 704: Difference between revisions
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The C-terminal region of LeuRS is composed of β-sheet surrounded by α-helices and an additional region (a structure with α- α - α topology), specific to this enzyme. At the tip of the long variable arm of tRNA Leu, there are four nucleotides: G47a, U47b, A47c and G47d which formed a loop. Some of these nucleotides interact with C-terminal residues through Van der Waals interactions and hydrogen bonds. | The C-terminal region of LeuRS is composed of β-sheet surrounded by α-helices and an additional region (a structure with α- α - α topology), specific to this enzyme. At the tip of the long variable arm of tRNA Leu, there are four nucleotides: G47a, U47b, A47c and G47d which formed a loop. Some of these nucleotides interact with C-terminal residues through Van der Waals interactions and hydrogen bonds. | ||
First, A47c and G47d which are turned outward of the loop interact with Pro962 and Glu967. | First, A47c and G47d which are turned outward of the loop interact with Pro962 and Glu967. | ||
Then, A47c interacts specifically with 3 residues: Ile849, Ile966 and Glu967. And G47d interacts with four residues: Ile 849, Ile964, Asp845 and Pro962. | Then, A47c interacts specifically with 3 residues: Ile849, Ile966 and Glu967. And G47d interacts with four residues: Ile 849, Ile964, Asp845 and Pro962. | ||
Both A47c and G47d recognition by C-terminal region of the enzyme are important for recognition of the variable arm and a correct translation process. | Both A47c and G47d recognition by C-terminal region of the enzyme are important for recognition of the variable arm and a correct translation process. | ||
