Sandbox Reserved 712: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 24: | Line 24: | ||
Darunavir shows a high genetical barrier to resistance development. In fact studies indicate that the development of resistance needs more specific mutations and develops more slowly. <ref> PMID:15917527 </ref> | Darunavir shows a high genetical barrier to resistance development. In fact studies indicate that the development of resistance needs more specific mutations and develops more slowly. <ref> PMID:15917527 </ref> | ||
Darunavir resistance-associated mutations are V11I, V32I, <scene name='Sandbox_Reserved_712/L33f/1'>L33F</scene>, I47V, I50V, I54L, I54M, G73S, L76V, <scene name='Sandbox_Reserved_712/I84v/2'>I84V</scene> and | Darunavir resistance-associated mutations are V11I, V32I, <scene name='Sandbox_Reserved_712/L33f/1'>L33F</scene>, I47V, I50V, I54L, I54M, G73S, L76V, <scene name='Sandbox_Reserved_712/I84v/2'>I84V</scene> and | ||
<scene name='Sandbox_Reserved_712/L89v/1'>L89V</scene>. Those mutations occurred in patients who have a high number of PI resistance-associated mutations. <ref> PMID:17416261 </ref> | <scene name='Sandbox_Reserved_712/L89v/1'>L89V</scene> ([[HIV Protease Resistance]]). Those mutations occurred in patients who have a high number of PI resistance-associated mutations. <ref> PMID:17416261 </ref> | ||
== '''Phenotypic susceptibility and enzymatic analysis''' == | == '''Phenotypic susceptibility and enzymatic analysis''' == | ||
