4ejn: Difference between revisions

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[[Image:4ejn.jpg|left|200px]]
[[Image:4ejn.png|left|200px]]


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{{STRUCTURE_4ejn|  PDB=4ejn  |  SCENE=  }}  
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===Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide===
===Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide===


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{{ABSTRACT_PUBMED_22533986}}
{{ABSTRACT_PUBMED_22533986}}


Revision as of 07:04, 2 January 2013

File:4ejn.png

Template:STRUCTURE 4ejn

Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide

Template:ABSTRACT PUBMED 22533986

About this Structure

4ejn is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Ashwell MA, Lapierre JM, Brassard C, Bresciano K, Bull C, Cornell-Kennon S, Eathiraj S, France D, Hall T, Hill J, Kelleher E, Khanapurkar S, Kizer D, Koerner S, Link J, Liu Y, Makhija S, Moussa M, Namdev N, Nicewonger R, Nguyen K, Palma R, Szwaya J, Tandon M, Uppalapati U, Vensel D, Volak LP, Volckova E, Westlund N, Wu H, Yang RY, Chan TC. Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl) pyridin-2-amines: Orally Bioavailable, Selective and Potent ATP-independent Akt Inhibitors. J Med Chem. 2012 Apr 25. PMID:22533986 doi:10.1021/jm300276x

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