Sandbox Reserved 714: Difference between revisions
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This enzyme is expressed in mammalian liver, vascular endothelium, proximal tubule and some smooth muscles. By hydrolyzing epoxides and lipid phosphates, it has a role in detoxification and it prevents DNA from alkylation by those epoxides. At the physiological level, hsEH participates to the regulation of cardiovascular and renal physiology and to inflammatory biology as well<ref>PMID:16322563</ref>. More specifically, this enzyme is a regulator of mammalian blood pressure and could be a target for a treatment of hypertension<ref>PMID:11001943</ref>. Thanks to mutagenesis experiments<ref>PMID:11882632</ref>, it has been demonstrated that the inhibition of sEH lowers blood pressure. | This enzyme is expressed in mammalian liver, vascular endothelium, proximal tubule and some smooth muscles. By hydrolyzing epoxides and lipid phosphates, it has a role in detoxification and it prevents DNA from alkylation by those epoxides. At the physiological level, hsEH participates to the regulation of cardiovascular and renal physiology and to inflammatory biology as well<ref>PMID:16322563</ref>. More specifically, this enzyme is a regulator of mammalian blood pressure and could be a target for a treatment of hypertension<ref>PMID:11001943</ref>. Thanks to mutagenesis experiments<ref>PMID:11882632</ref>, it has been demonstrated that the inhibition of sEH lowers blood pressure. | ||
== Structure == | |||
<StructureSection load='1s8o_mm1.pdb' size='400' side='left' caption='X-ray crystal structure of hsEH (PDB entry [[1s8o]])' scene='Sandbox_Reserved_714/Initial_scene/2'> | <StructureSection load='1s8o_mm1.pdb' size='400' side='left' caption='X-ray crystal structure of hsEH (PDB entry [[1s8o]])' scene='Sandbox_Reserved_714/Initial_scene/2'> | ||
