Sandbox Reserved 709: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Marmin Lucas (talk | contribs) |
Marmin Lucas (talk | contribs) |
||
| Line 56: | Line 56: | ||
Here you can see a <scene name='Sandbox_Reserved_709/Nls_basic/1'>NLS </scene>bound to the NLS-binding site of importin α. | Here you can see a <scene name='Sandbox_Reserved_709/Nls_basic/1'>NLS </scene>bound to the NLS-binding site of importin α. | ||
* '''A NLS'''. Thus, importin α belongs to the group of proteins containing both a ligand (NLS) and a cognate receptor (NLS-binding site). That’s why it could have a possibility of autologous ligand-receptor interactions. Nevertheless, it has been shown that NLS of importin α overlaps with the IBB. Thereby, binding of importin β to importin α covers the NLS of importin α preventing autologous ligand receptor interactions. | * '''A NLS'''. Thus, importin α belongs to the group of proteins containing both a ligand (NLS) and a cognate receptor (NLS-binding site). That’s why it could have a possibility of autologous ligand-receptor interactions. Nevertheless, it has been shown that NLS of importin α overlaps with the IBB. Thereby, binding of importin β to importin α covers the NLS of importin α preventing autologous ligand receptor interactions. <ref>PMID:8692858</ref> | ||
As for the IBB, this NLS domain is not visible in this structure as it is located in the 45-54 region. However, the overlap of the NLS by the IBB is proved by this information. | As for the IBB, this NLS domain is not visible in this structure as it is located in the 45-54 region. However, the overlap of the NLS by the IBB is proved by this information. | ||
