Sandbox Reserved 704: Difference between revisions
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The C-terminal region of LeuRS is composed of β-sheet surrounded by α-helices and an additional region (a structure with α- α - α topology), specific to this enzyme. At the tip of the long variable arm of tRNA Leu, there are four nucleotides: G47a, U47b, A47c and G47d which formed a loop. Some of these nucleotides interact with C-terminal residues through Van der Waals interactions and hydrogen bonds. | The C-terminal region of LeuRS is composed of β-sheet surrounded by α-helices and an additional region (a structure with α- α - α topology), specific to this enzyme. At the tip of the long variable arm of tRNA Leu, there are four nucleotides: G47a, U47b, A47c and G47d which formed a loop. Some of these nucleotides interact with C-terminal residues through Van der Waals interactions and hydrogen bonds. | ||
First, A47c and G47d which are turned outward of the loop interact with <scene name='Sandbox_Reserved_704/Pro962/2'>Pro962</scene> and <scene name='Sandbox_Reserved_704/Glu_967/1'>Glu967</scene>. | First, A47c and G47d which are turned outward of the loop interact with <scene name='Sandbox_Reserved_704/Pro962/2'>Pro962</scene> and <scene name='Sandbox_Reserved_704/Glu_967/1'>Glu967</scene>. | ||
Then, A47c interacts specifically with <scene name='Sandbox_Reserved_704/Ile849_ile966_glu967/1'>3_residues</scene>: Ile849, Ile966 and Glu967. And G47d interacts with | Then, A47c interacts specifically with <scene name='Sandbox_Reserved_704/Ile849_ile966_glu967/1'>3_residues</scene>: Ile849, Ile966 and Glu967. And G47d interacts with <scene name='Sandbox_Reserved_704/4_residues/1'>4 residues</scene>: Ile 849, Ile964, Asp845 and Pro962. | ||
Both A47c and G47d recognition by C-terminal region of the enzyme are important for recognition of the variable arm and a correct translation process <ref name="">PMID:16155584</ref>. | Both A47c and G47d recognition by C-terminal region of the enzyme are important for recognition of the variable arm and a correct translation process <ref name="">PMID:16155584</ref>. | ||
