Sandbox Reserved 709: Difference between revisions
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Marmin Lucas (talk | contribs) m formatting |
Marmin Lucas (talk | contribs) m captions |
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===Cytoplasm to nucleus=== | ===Cytoplasm to nucleus=== | ||
[[Image:Nuclear_import_protein.png | 600px | right |thumb]] | [[Image:Nuclear_import_protein.png | 600px | right |thumb|Nuclear import of proteins through importins α and β]] | ||
To initiate the transport to the nucleus, most of the NLS-containing proteins (or cargos) have to be recognized by a '''Nuclear Import Receptor'''. These are soluble cytosolic proteins such as '''importin α''' and '''[[Importin β|importin β]]'''. | To initiate the transport to the nucleus, most of the NLS-containing proteins (or cargos) have to be recognized by a '''Nuclear Import Receptor'''. These are soluble cytosolic proteins such as '''importin α''' and '''[[Importin β|importin β]]'''. | ||
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''(<scene name='Sandbox_Reserved_709/Importin_default/1'>Back to the default scene</scene>)'' | ''(<scene name='Sandbox_Reserved_709/Importin_default/1'>Back to the default scene</scene>)'' | ||
<Structure load='1ejy' size='300' color='white' frame='true' align='right' caption='Mouse importin α bound to a NLS of a peptide' scene='Sandbox_Reserved_709/Importin_default/1' /> | <Structure load='1ejy' size='300' color='white' frame='true' align='right' caption='Mouse importin α bound to a NLS of a peptide (PDB 1ejy)' scene='Sandbox_Reserved_709/Importin_default/1' /> | ||
'''Importin α''' is a soluble adaptor protein also known as '''karyopherin α'''. Its function is to bind a protein containing a cNLS (''classical Nuclear Localization Signal'') and then to bind an importin β in order to help the import of this protein in the nucleus. | '''Importin α''' is a soluble adaptor protein also known as '''karyopherin α'''. Its function is to bind a protein containing a cNLS (''classical Nuclear Localization Signal'') and then to bind an importin β in order to help the import of this protein in the nucleus. | ||
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==Importin α : Nup50 complex== | ==Importin α : Nup50 complex== | ||
<Structure load='2c1m' size='300' color='white' frame='true' align='right' scene='Sandbox_Reserved_709/Impnup_default/2' caption=' | <Structure load='2c1m' size='300' color='white' frame='true' align='right' scene='Sandbox_Reserved_709/Impnup_default/2' caption='Mouse importin α:Nup50 complex (PDB 2c1m) /> | ||
''(<scene name='Sandbox_Reserved_709/Impnup_default/2'>Back to Default scene </scene>)'' | ''(<scene name='Sandbox_Reserved_709/Impnup_default/2'>Back to Default scene </scene>)'' | ||
