1u6q: Difference between revisions
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==Overview== | ==Overview== | ||
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase | A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors. | ||
==Disease== | ==Disease== | ||
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[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
[[Category: Bruncko, M.]] | [[Category: Bruncko, M.]] | ||
[[Category: Dalton, C | [[Category: Dalton, C R.]] | ||
[[Category: Geyer, A.]] | [[Category: Geyer, A.]] | ||
[[Category: Giranda, V | [[Category: Giranda, V L.]] | ||
[[Category: Kaminski, M | [[Category: Kaminski, M K.]] | ||
[[Category: McClellan, W.]] | [[Category: McClellan, W.]] | ||
[[Category: Nienaber, V | [[Category: Nienaber, V L.]] | ||
[[Category: Rockway, T | [[Category: Rockway, T R.]] | ||
[[Category: Sauer, D | [[Category: Sauer, D R.]] | ||
[[Category: Wendt, M | [[Category: Wendt, M D.]] | ||
[[Category: 745]] | [[Category: 745]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:21:08 2008'' | ||
Revision as of 13:21, 21 February 2008
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Substituted 2-Naphthamadine inhibitors of Urokinase
Overview
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
1U6Q is a Single protein structure of sequence from Homo sapiens with 745 as ligand. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.
Reference
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties., Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL, Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. PMID:15582418
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