Sandbox Reserved 707: Difference between revisions
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== B-RAF Structure<ref>PMID: 15035987</ref> == | == B-RAF Structure<ref>PMID: 15035987</ref> == | ||
As we distinguished before, there are 3 types of RAF proteins: A-RAF, B-RAF and C-RAF. All of them share 3 much conserved regions (CR): CR1, CR2 and <scene name='Sandbox_Reserved_707/Cr3_domain/2'>CR3</scene>. We have to say here that in the pdb file 1UWH the protein is already dimerized (as we will say it in the next part), and so we have here '''two''' CR3 domains. <br /> | As we distinguished before, there are 3 types of RAF proteins: A-RAF, B-RAF and C-RAF. All of them share 3 much conserved regions (CR): CR1, CR2 and <scene name='Sandbox_Reserved_707/Cr3_domain/2'>CR3</scene>. We have to say here that in the pdb file 1UWH the protein is already dimerized (as we will say it in the next part), and so we have here '''two''' CR3 domains. <br /> | ||
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<scene name='Sandbox_Reserved_707/Cr3_domain/2'>CR3</scene> is the protein kinase domain on the C-terminal region. We can find just after this kinase domain a stimulatory 14-3-3 binding site for other regulatory proteins.<br /> | <scene name='Sandbox_Reserved_707/Cr3_domain/2'>CR3</scene> is the protein kinase domain on the C-terminal region. We can find just after this kinase domain a stimulatory 14-3-3 binding site for other regulatory proteins.<br /> | ||
[[Image:1-s2.0-S0092867404002156-main page7 image1.jpg|400px|thumb| A. Structure of B-RAF Kinase Domain <br /> | |||
B. Schematic B-RAF Primary Structure]] | |||
As all RAF Proteins, B-RAF has the characteristic <scene name='Sandbox_Reserved_707/Small_lobe/1'>small N-terminal lobe</scene> and the <scene name='Sandbox_Reserved_707/Large_lobe/1'>large C-terminal lobe</scene>. | As all RAF Proteins, B-RAF has the characteristic <scene name='Sandbox_Reserved_707/Small_lobe/1'>small N-terminal lobe</scene> and the <scene name='Sandbox_Reserved_707/Large_lobe/1'>large C-terminal lobe</scene>. | ||
