Sandbox Reserved 707: Difference between revisions
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In a third study, Hatzivassiliou and colleagues reported that RAF inhibitor treatment results in the paradoxical induction of phospho-MEK and phospho-ERK levels in the wild-type RAS/RAF human Melanoma. They showed that knockdown of C-RAF, but not B-RAF, in human colorectal carcinoma | In a third study, Hatzivassiliou and colleagues reported that RAF inhibitor treatment results in the paradoxical induction of phospho-MEK and phospho-ERK levels in the wild-type RAS/RAF human Melanoma<ref>PMID:20141835</ref>. They showed that knockdown of C-RAF, but not B-RAF, in human colorectal carcinoma | ||
HCT116 (mutant K-RAS) cells reverses the phospho-MEK induction observed after RAF inhibitor treatment, indicating that C-RAF has a major role in signaling to MEK, a result that is in agreement with the above two studies. <br /> | HCT116 (mutant K-RAS) cells reverses the phospho-MEK induction observed after RAF inhibitor treatment, indicating that C-RAF has a major role in signaling to MEK, a result that is in agreement with the above two studies. <br /> | ||
