Sandbox Reserved 706: Difference between revisions
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Rab27B binds to Slac2-a with good shape complementarity and this interaction involves many hydrophobic interactions and several electrostatic interactions. | Rab27B binds to Slac2-a with good shape complementarity and this interaction involves many hydrophobic interactions and several electrostatic interactions. | ||
There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | ||
*The first contact area of the Rab27B/Slac2-a interface consists of residues 6–9 from the Rab complementarity-determining regions (RabCDR) , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (also see figure 3A) | *The first contact area of the Rab27B/Slac2-a interface consists of residues 6–9 from the Rab complementarity-determining regions (RabCDR) , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (also see figure 3A) | ||
