1usx: Difference between revisions

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==Overview==

Paramyxoviruses are the leading cause of respiratory disease in children., Several paramyxoviruses possess a surface glycoprotein, the, hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic, acid receptors, promotion of fusion, and removal of sialic acid from, infected cells and progeny virions. Previously we showed that Newcastle, disease virus (NDV) HN contained a pliable sialic acid recognition site, that could take two states, a binding state and a catalytic state. Here we, present evidence for a second sialic acid binding site at the dimer, interface of HN and present a model for its involvement in cell fusion., Three different crystal forms of NDV HN now reveal identical tetrameric, arrangements of HN monomers, perhaps indicative of the tetramer, association found on the viral surface.

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.

==About this Structure==

Line 15:

[[Category: Single protein]]

[[Category: Groves, D.]]

[[Category: Itzstein, M.Von.]]

[[Category: Itzstein, M Von.]]

[[Category: Kiefel, M.]]

[[Category: Portner, A.]]

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[[Category: sialidase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:27:54 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Paramyxoviruses are the leading cause of respiratory disease in children., Several paramyxoviruses possess a surface glycoprotein, the, hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic, acid receptors, promotion of fusion, and removal of sialic acid from, infected cells and progeny virions. Previously we showed that Newcastle, disease virus (NDV) HN contained a pliable sialic acid recognition site, that could take two states, a binding state and a catalytic state. Here we, present evidence for a second sialic acid binding site at the dimer, interface of HN and present a model for its involvement in cell fusion., Three different crystal forms of NDV HN now reveal identical tetrameric, arrangements of HN monomers, perhaps indicative of the tetramer, association found on the viral surface.
+Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Single protein]]
 [[Category: Groves, D.]]
-[[Category: Itzstein, M.Von.]]
+[[Category: Itzstein, M Von.]]
 [[Category: Kiefel, M.]]
 [[Category: Portner, A.]]
@@ Line 30: / Line 30: @@
 [[Category: sialidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:04:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:27:54 2008''