Sandbox Reserved 706: Difference between revisions
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Rab27B adopt a globular form in the complex and Slac2-a forms an elongated helical fold with a subdomain that contain two zinc ions. | Rab27B adopt a globular form in the complex and Slac2-a forms an elongated helical fold with a subdomain that contain two zinc ions. | ||
'''Interface of Rab27B/Slac2-a and interaction details:''' | '''Interface of Rab27B/Slac2-a and interaction details:''' | ||
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Rab27B binds to Slac2-a with good shape complementarity and this interaction involves many hydrophobic interactions and several electrostatic interactions. | Rab27B binds to Slac2-a with good shape complementarity and this interaction involves many hydrophobic interactions and several electrostatic interactions. | ||
There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | ||
[[Image:Rab27B slac2a image3.gif | 425 px | thumb | left |Picture 3: Caption: ]] | |||
*The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/2'> residues 6 to 9 from the Rab complementarity-determining regions (RabCDR)</scene> , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (see figure 3A) | *The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/2'> residues 6 to 9 from the Rab complementarity-determining regions (RabCDR)</scene> , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (see figure 3A) | ||
