1vjy: Difference between revisions
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New page: left|200px<br /> <applet load="1vjy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vjy, resolution 2.0Å" /> '''Crystal Structure of... |
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[[Image:1vjy.gif|left|200px]]<br /> | [[Image:1vjy.gif|left|200px]]<br /><applet load="1vjy" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1vjy" size=" | |||
caption="1vjy, resolution 2.0Å" /> | caption="1vjy, resolution 2.0Å" /> | ||
'''Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor'''<br /> | '''Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor'''<br /> | ||
==Overview== | ==Overview== | ||
Optimization of the screening hit 1 led to the identification of novel | Optimization of the screening hit 1 led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-beta type I receptor, ALK5. Compounds 15 and 19, which inhibited ALK5 autophosphorylation with IC50 = 6 and 4 nM, respectively, showed potent activities in both binding and cellular assays and exhibited selectivity over p38 mitogen-activated protein kinase. The X-ray crystal structure of 19 in complex with human ALK5 is described, confirming the binding mode proposed from docking studies. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1VJY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 460 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 1VJY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=460:'>460</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJY OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Boullay, V.]] | [[Category: Boullay, V.]] | ||
[[Category: Fouchet, M | [[Category: Fouchet, M H.]] | ||
[[Category: Gellibert, F.]] | [[Category: Gellibert, F.]] | ||
[[Category: Goodland, H.]] | [[Category: Goodland, H.]] | ||
[[Category: Gouville, A | [[Category: Gouville, A C.de.]] | ||
[[Category: Hartley, D.]] | [[Category: Hartley, D.]] | ||
[[Category: Huet, S.]] | [[Category: Huet, S.]] | ||
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[[Category: Lovegrove, V.]] | [[Category: Lovegrove, V.]] | ||
[[Category: Mathews, N.]] | [[Category: Mathews, N.]] | ||
[[Category: Nguyen, V | [[Category: Nguyen, V L.]] | ||
[[Category: Sautet, S.]] | [[Category: Sautet, S.]] | ||
[[Category: Smith, W.]] | [[Category: Smith, W.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:36:07 2008'' | ||
