Sandbox Reserved 706: Difference between revisions
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Rab27B–GTP adopts a compact monomer conformation, while an extended conformation is observed for GDP-bound Rab27B. | Rab27B–GTP adopts a compact monomer conformation, while an extended conformation is observed for GDP-bound Rab27B. | ||
<scene name='Sandbox_Reserved_706/Switch_1_rab27b/1'>Switch 1</scene> and <scene name='Sandbox_Reserved_706/Switch2_rab27b/1'>switch 2</scene> of Rab27B play an important role in this changing of conformation. In fact, switch 1 and 2 allow GTP binding by making hydrogen bond with GTP's γ-phosphate, and this way also allows Slac2-a binding. But in the complex Rab27B/GDP switch 1 and switch 2 exist completely apart from the bound GDP, so there is no interaction with Slac2-a and no binding. | <scene name='Sandbox_Reserved_706/Switch_1_rab27b/1'>Switch 1</scene> and <scene name='Sandbox_Reserved_706/Switch2_rab27b/1'>switch 2</scene> of Rab27B play an important role in this changing of conformation. In fact, switch 1 and 2 allow GTP binding by making hydrogen bond with GTP's γ-phosphate, and this way also allows Slac2-a binding. But in the complex Rab27B/GDP switch 1 and switch 2 exist completely apart from the bound GDP, so there is no interaction with Slac2-a and no binding. | ||
=== '''Structure of Slac2-a''' === | === '''Structure of Slac2-a''' === | ||
