Sandbox Reserved 706: Difference between revisions
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The structure of the Slac2-a effector domain comprises three subdomains: SHD1, SHD2, and a zinc-binding subdomain that is flanked by the two SHDs. <ref>PMID:11856727</ref> | The structure of the Slac2-a effector domain comprises three subdomains: SHD1, SHD2, and a zinc-binding subdomain that is flanked by the two SHDs. <ref>PMID:11856727</ref> | ||
SHD1 is folded into a 66 Å <scene name='Sandbox_Reserved_706/Helice_1_de_slac2a/1'>lond helix alpha 1</scene>, and SHD2 is composed of <scene name='Sandbox_Reserved_706/Alpha_3_5_shd2/3'>three alpha helices, alpha 3 to alpha 5</scene>. SHD1 and SHD2 interact with each other by making a coiled coil between α1 and α3–α5. In this coiled coil, α3 and α5 interact with α1 in an antiparallel manner (see figure 2). | SHD1 is folded into a 66 Å <scene name='Sandbox_Reserved_706/Helice_1_de_slac2a/1'>lond helix alpha 1</scene>, and SHD2 is composed of <scene name='Sandbox_Reserved_706/Alpha_3_5_shd2/3'>three alpha helices, alpha 3 to alpha 5</scene>. SHD1 and SHD2 interact with each other by making a coiled coil between α1 and α3–α5. In this coiled coil, α3 and α5 interact with α1 in an antiparallel manner (see figure 2). | ||
The <scene name='Sandbox_Reserved_706/Zinc_binding_domain_slac2a/1'>zinc-binding subdomain</scene> contains four short {{Template:ColorKey_Strand}} (ß1–ß4) and five loops(L1-L5), including one short {{Template:ColorKey_Helix}} α2 and three short helices (in | The <scene name='Sandbox_Reserved_706/Zinc_binding_domain_slac2a/1'>zinc-binding subdomain</scene> contains four short {{Template:ColorKey_Strand}} (ß1–ß4) and five loops(L1-L5), including one short {{Template:ColorKey_Helix}} α2 and three short helices (in purple). The <scene name='Sandbox_Reserved_706/Zn1_et_zn2_de_slac2a/1'>two zinc ions (Zn1 and Zn2)</scene> are each coordinated by four conserved cysteine residues: | ||
<scene name='Sandbox_Reserved_706/Cys_64_67_89_92/2'>Cys64, Cys67, Cys89 and Cys92</scene> for Zn1 binding, and <scene name='Sandbox_Reserved_706/Cys81_cys84_cys104_cys107/2'>Cys81, Cys84, Cys104, and Cys107</scene> for Zn2 binding. <ref>PMID:18940604</ref> | <scene name='Sandbox_Reserved_706/Cys_64_67_89_92/2'>Cys64, Cys67, Cys89 and Cys92</scene> for Zn1 binding, and <scene name='Sandbox_Reserved_706/Cys81_cys84_cys104_cys107/2'>Cys81, Cys84, Cys104, and Cys107</scene> for Zn2 binding. <ref>PMID:18940604</ref> | ||
<Structure load='2ZET' size='500' frame='true' align='right' caption='Final model of 2zet: Two Rab27B/Slac2-a complexes (A/C and B/D)' scene='Insert optional scene name here' /> | <Structure load='2ZET' size='500' frame='true' align='right' caption='Final model of 2zet: Two Rab27B/Slac2-a complexes (A/C and B/D)' scene='Insert optional scene name here' /> | ||
=== '''Structure of the complex''' === | === '''Structure of the complex''' === | ||
