Ferrochelatase: Difference between revisions
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Michal Harel (talk | contribs) New page: '''Ferrochelatase''' (FECH) catalyzes the last step in the formation of heme. FECH adds Fe+2 to protoporphyrin IX converting it to protoheme. The human FECH is a homodimer containing ... |
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{{STRUCTURE_2qd3| PDB=2qd3 | SIZE=400| SCENE= |right|CAPTION=Human ferrochelatase with protoporpohyrin and Fe2S2 cluster, [[2qd3]] }} | |||
'''Ferrochelatase''' (FECH) catalyzes the last step in the formation of heme. FECH adds Fe+2 to protoporphyrin IX converting it to protoheme. The human FECH is a homodimer containing 2 similar domains and an iron-sulfur cluster. Defective FECH is the cause of porphyria. | '''Ferrochelatase''' (FECH) catalyzes the last step in the formation of heme. FECH adds Fe+2 to protoporphyrin IX converting it to protoheme. The human FECH is a homodimer containing 2 similar domains and an iron-sulfur cluster. Defective FECH is the cause of porphyria. | ||
==3D structures of ferrochelatase== | ==3D structures of ferrochelatase== | ||
[[1ak1]] – BsFECH – Bacillus subtilis<br /> | [[1ak1]] – BsFECH – ''Bacillus subtilis''<br /> | ||
[[2ac4]] - BsFECH (mutant) <br /> | [[2ac4]] - BsFECH (mutant) <br /> | ||
[[1doz]] - BsFECH + Mg<br /> | [[1doz]] - BsFECH + Mg<br /> | ||
