2hs2: Difference between revisions

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{{Seed}}
[[Image:2hs2.png|left|200px]]
[[Image:2hs2.png|left|200px]]


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{{STRUCTURE_2hs2|  PDB=2hs2  |  SCENE=  }}  
{{STRUCTURE_2hs2|  PDB=2hs2  |  SCENE=  }}  


===Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)===
===Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)===


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{{ABSTRACT_PUBMED_16962136}}
{{ABSTRACT_PUBMED_16962136}}


==About this Structure==
==About this Structure==
2HS2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS2 OCA].  
[[2hs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS2 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:16962136</ref><references group="xtra"/>
<ref group="xtra">PMID:016962136</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Kovalevsky, A Y.]]
[[Category: Kovalevsky, A Y.]]
Line 29: Line 18:
[[Category: Weber, I T.]]
[[Category: Weber, I T.]]
[[Category: Aspartic protease active site surface binding site]]
[[Category: Aspartic protease active site surface binding site]]
 
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:15:50 2009''

Revision as of 10:44, 7 January 2013

File:2hs2.png

Template:STRUCTURE 2hs2

Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)

Template:ABSTRACT PUBMED 16962136

About this Structure

2hs2 is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  1. Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007

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