1w2k: Difference between revisions
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==Overview== | ==Overview== | ||
Proof of concept experiments have shown that tissue factor/factor VIIa | Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling. | ||
==Disease== | ==Disease== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Ackermann, J.]] | [[Category: Ackermann, J.]] | ||
[[Category: Arcy, A | [[Category: Arcy, A D.]] | ||
[[Category: Banner, D | [[Category: Banner, D W.]] | ||
[[Category: Groebke-Zbinden, K.]] | [[Category: Groebke-Zbinden, K.]] | ||
[[Category: Ji, Y.]] | [[Category: Ji, Y.]] | ||
[[Category: Kirchhofer, D.]] | [[Category: Kirchhofer, D.]] | ||
[[Category: Tschopp, T | [[Category: Tschopp, T B.]] | ||
[[Category: Wallbaum, S.]] | [[Category: Wallbaum, S.]] | ||
[[Category: Weber, L.]] | [[Category: Weber, L.]] | ||
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[[Category: vitamin k]] | [[Category: vitamin k]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:45 2008'' | ||
