1w31: Difference between revisions

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==Overview==

The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase, (ALAD) from yeast complexed with the competitive inhibitor, 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The, structure shows that the inhibitor is bound by a Schiff-base link to one, of the invariant active-site lysine residues (Lys263). The inhibitor, appears to bind in two well defined conformations and the interactions, made by it suggest that it is a very close analogue of the substrate, 5-aminolaevulinic acid (ALA).

The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).

==About this Structure==

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[[Category: Saccharomyces cerevisiae]]

[[Category: Single protein]]

[[Category: Beaven, G.D.E.]]

[[Category: Beaven, G D.E.]]

[[Category: Brindley, A.A.]]

[[Category: Brindley, A A.]]

[[Category: Coates, L.]]

[[Category: Cooper, J.B.]]

[[Category: Cooper, J B.]]

[[Category: Erskine, P.T.]]

[[Category: Erskine, P T.]]

[[Category: Gill, R.]]

[[Category: Neier, R.]]

[[Category: Newbold, R.]]

[[Category: Shoolingin-Jordan, P.M.]]

[[Category: Shoolingin-Jordan, P M.]]

[[Category: Stauffer, F.]]

[[Category: Warren, M.J.]]

[[Category: Warren, M J.]]

[[Category: Wood, S.P.]]

[[Category: Wood, S P.]]

[[Category: SHO]]

[[Category: ZN]]

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[[Category: zinc]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:55 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase, (ALAD) from yeast complexed with the competitive inhibitor, 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The, structure shows that the inhibitor is bound by a Schiff-base link to one, of the invariant active-site lysine residues (Lys263). The inhibitor, appears to bind in two well defined conformations and the interactions, made by it suggest that it is a very close analogue of the substrate, 5-aminolaevulinic acid (ALA).
+The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
-[[Category: Beaven, G.D.E.]]
+[[Category: Beaven, G D.E.]]
-[[Category: Brindley, A.A.]]
+[[Category: Brindley, A A.]]
 [[Category: Coates, L.]]
-[[Category: Cooper, J.B.]]
+[[Category: Cooper, J B.]]
-[[Category: Erskine, P.T.]]
+[[Category: Erskine, P T.]]
 [[Category: Gill, R.]]
 [[Category: Neier, R.]]
 [[Category: Newbold, R.]]
-[[Category: Shoolingin-Jordan, P.M.]]
+[[Category: Shoolingin-Jordan, P M.]]
 [[Category: Stauffer, F.]]
-[[Category: Warren, M.J.]]
+[[Category: Warren, M J.]]
-[[Category: Wood, S.P.]]
+[[Category: Wood, S P.]]
 [[Category: SHO]]
 [[Category: ZN]]
@@ Line 36: / Line 36: @@
 [[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:18:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:55 2008''