1w33: Difference between revisions
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==Overview== | ==Overview== | ||
Borrelia burgdorferi, a spirochete transmitted to human hosts during | Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Brade, V.]] | [[Category: Brade, V.]] | ||
[[Category: Cordes, F | [[Category: Cordes, F S.]] | ||
[[Category: Goodstadt, L.]] | [[Category: Goodstadt, L.]] | ||
[[Category: Kirschfink, M.]] | [[Category: Kirschfink, M.]] | ||
[[Category: Kraiczy, P.]] | [[Category: Kraiczy, P.]] | ||
[[Category: Lea, S | [[Category: Lea, S M.]] | ||
[[Category: Ponting, C.]] | [[Category: Ponting, C.]] | ||
[[Category: Roversi, P.]] | [[Category: Roversi, P.]] | ||
[[Category: Simon, M | [[Category: Simon, M M.]] | ||
[[Category: Skerka, C.]] | [[Category: Skerka, C.]] | ||
[[Category: Wallich, R.]] | [[Category: Wallich, R.]] | ||
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[[Category: tick]] | [[Category: tick]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:55 2008'' | ||
