2np8: Difference between revisions

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{{Seed}}
[[Image:2np8.png|left|200px]]
[[Image:2np8.png|left|200px]]


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{{STRUCTURE_2np8|  PDB=2np8  |  SCENE=  }}  
{{STRUCTURE_2np8|  PDB=2np8  |  SCENE=  }}  


===Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors===
===Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors===


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{{ABSTRACT_PUBMED_17157005}}
{{ABSTRACT_PUBMED_17157005}}
==Disease==
Known disease associated with this structure: Colon cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603072 603072]]


==About this Structure==
==About this Structure==
2NP8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NP8 OCA].  
[[2np8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NP8 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:17157005</ref><references group="xtra"/>
<ref group="xtra">PMID:017157005</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Kinase inhibitor]]
[[Category: Kinase inhibitor]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep  3 16:25:29 2009''

Revision as of 13:33, 7 January 2013

File:2np8.png

Template:STRUCTURE 2np8

Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors

Template:ABSTRACT PUBMED 17157005

About this Structure

2np8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Tari LW, Hoffman ID, Bensen DC, Hunter MJ, Nix J, Nelson KJ, McRee DE, Swanson RV. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. Epub 2006 Nov 2. PMID:17157005 doi:https://dx.doi.org/10.1016/j.bmcl.2006.10.086

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