1wq6: Difference between revisions
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New page: left|200px<br /> <applet load="1wq6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wq6, resolution 2.00Å" /> '''The tetramer struct... |
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[[Image:1wq6.gif|left|200px]]<br /> | [[Image:1wq6.gif|left|200px]]<br /><applet load="1wq6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1wq6" size=" | |||
caption="1wq6, resolution 2.00Å" /> | caption="1wq6, resolution 2.00Å" /> | ||
'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br /> | '''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br /> | ||
==Overview== | ==Overview== | ||
AML1/ETO is the chimeric protein resulting from the t(8;21) in acute | AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules. | ||
==About this Structure== | ==About this Structure== | ||
1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bushweller, J | [[Category: Bushweller, J H.]] | ||
[[Category: Cheney, M | [[Category: Cheney, M D.]] | ||
[[Category: Chruszcz, M.]] | [[Category: Chruszcz, M.]] | ||
[[Category: Dauter, Z.]] | [[Category: Dauter, Z.]] | ||
[[Category: Hartman, K | [[Category: Hartman, K L.]] | ||
[[Category: Laue, T | [[Category: Laue, T M.]] | ||
[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
[[Category: Lukasik, S | [[Category: Lukasik, S M.]] | ||
[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
[[Category: Speck, N | [[Category: Speck, N A.]] | ||
[[Category: aml1-eto]] | [[Category: aml1-eto]] | ||
[[Category: eto]] | [[Category: eto]] | ||
[[Category: nhr2]] | [[Category: nhr2]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:02 2008'' | ||
