2h6m: Difference between revisions

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{{Seed}}
[[Image:2h6m.png|left|200px]]
[[Image:2h6m.png|left|200px]]


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{{STRUCTURE_2h6m|  PDB=2h6m  |  SCENE=  }}  
{{STRUCTURE_2h6m|  PDB=2h6m  |  SCENE=  }}  


===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors===
===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors===


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{{ABSTRACT_PUBMED_16860823}}
{{ABSTRACT_PUBMED_16860823}}


==About this Structure==
==About this Structure==
2H6M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6M OCA].  
[[2h6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6M OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:16860823</ref><references group="xtra"/>
<ref group="xtra">PMID:016860823</ref><ref group="xtra">PMID:016288920</ref><references group="xtra"/>
[[Category: Hepatitis a virus]]
[[Category: Hepatitis a virus]]
[[Category: Picornain 3C]]
[[Category: Picornain 3C]]
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[[Category: Yin, J.]]
[[Category: Yin, J.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
 
[[Category: Hydrolase-hydrolase inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:53:24 2009''

Revision as of 15:04, 7 January 2013

File:2h6m.png

Template:STRUCTURE 2h6m

An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors

Template:ABSTRACT PUBMED 16860823

About this Structure

2h6m is a 2 chain structure with sequence from Hepatitis a virus. Full crystallographic information is available from OCA.

Reference

  1. Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:16860823 doi:10.1016/j.jmb.2006.06.047
  2. Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:16288920 doi:10.1016/j.jmb.2005.09.074

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