1x11: Difference between revisions

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[[Image:1x11.gif|left|200px]]<br />

[[Image:1x11.gif|left|200px]]<br /><applet load="1x11" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1x11" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1x11, resolution 2.5Å" />

'''X11 PTB DOMAIN'''<br />

==Overview==

The crystal structure of the phosphotyrosine-binding domain (PTB) of the, X11 protein has been determined, in complex with unphosphorylated peptides, corresponding to a region of beta-amyloid precursor protein (betaAPP) that, is required for receptor internalization. The mode of binding to X11 of, the unphosphorylated peptides, which contain an NPxY motif, resembles that, of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight, peptide residues make specific contacts with the X11 PTB domain, and they, collectively achieve high affinity (KD = 0.32 microM) and specificity., These results suggest that, in contrast to the SH2 domains, the PTB, domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.

The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.

==Disease==

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==About this Structure==

1X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA].

1X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA].

==Reference==

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[[Category: Protein complex]]

[[Category: Kuriyan, J.]]

[[Category: Lee, C.H.]]

[[Category: Lee, C H.]]

[[Category: Zhang, Z.]]

[[Category: complex (peptide binding module/peptide)]]

[[Category: ptb domain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:57:~~37 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:50:03 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1x11.gif|left|200px]]<br />
+[[Image:1x11.gif|left|200px]]<br /><applet load="1x11" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1x11" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1x11, resolution 2.5&Aring;" />
 '''X11 PTB DOMAIN'''<br />
 ==Overview==
-The crystal structure of the phosphotyrosine-binding domain (PTB) of the, X11 protein has been determined, in complex with unphosphorylated peptides, corresponding to a region of beta-amyloid precursor protein (betaAPP) that, is required for receptor internalization. The mode of binding to X11 of, the unphosphorylated peptides, which contain an NPxY motif, resembles that, of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight, peptide residues make specific contacts with the X11 PTB domain, and they, collectively achieve high affinity (KD = 0.32 microM) and specificity., These results suggest that, in contrast to the SH2 domains, the PTB, domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
+The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA].
+X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Protein complex]]
 [[Category: Kuriyan, J.]]
-[[Category: Lee, C.H.]]
+[[Category: Lee, C H.]]
 [[Category: Zhang, Z.]]
 [[Category: complex (peptide binding module/peptide)]]
 [[Category: ptb domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:57:37 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:50:03 2008''