2rfs: Difference between revisions

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{{Seed}}
[[Image:2rfs.png|left|200px]]
[[Image:2rfs.png|left|200px]]


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{{STRUCTURE_2rfs|  PDB=2rfs  |  SCENE=  }}  
{{STRUCTURE_2rfs|  PDB=2rfs  |  SCENE=  }}  


===X-ray structure of SU11274 bound to c-Met===
===X-ray structure of SU11274 bound to c-Met===


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{{ABSTRACT_PUBMED_18055465}}
{{ABSTRACT_PUBMED_18055465}}
==Disease==
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]


==About this Structure==
==About this Structure==
2RFS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFS OCA].  
[[2rfs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFS OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:18055465</ref><references group="xtra"/>
<ref group="xtra">PMID:018055465</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
Line 47: Line 32:
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:34:56 2009''

Revision as of 21:05, 7 January 2013

File:2rfs.png

Template:STRUCTURE 2rfs

X-ray structure of SU11274 bound to c-Met

Template:ABSTRACT PUBMED 18055465

About this Structure

2rfs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bellon SF, Kaplan-Lefko P, Yang Y, Zhang Y, Moriguchi J, Rex K, Johnson CW, Rose PE, Long AM, O'Connor AB, Gu Y, Coxon A, Kim TS, Tasker A, Burgess TL, Dussault I. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem. 2008 Feb 1;283(5):2675-83. Epub 2007 Nov 30. PMID:18055465 doi:10.1074/jbc.M705774200

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