1y12: Difference between revisions

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[[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1y12, resolution 1.95Å" />

'''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''<br />

==Overview==

Bacterial pathogens frequently use protein secretion to mediate, interactions with their hosts. Here we found that a virulence locus, (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus., The apparatus assembled in discrete subcellular locations and exported, Hcp1, a hexameric protein that forms rings with a 40 angstrom internal, diameter. Regulatory patterns of HSI-I suggested that the apparatus, functions during chronic infections. We detected Hcp1 in pulmonary, secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies, in their sera. Thus, HSI-I likely contributes to the pathogenesis of P., aeruginosa in CF patients. HSI-I-related loci are widely distributed among, bacterial pathogens and may play a general role in mediating host, interactions.

Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.

==About this Structure==

1Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA].

1Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA].

==Reference==

Line 13:

[[Category: Pseudomonas aeruginosa]]

[[Category: Single protein]]

[[Category: Cuff, M.E.]]

[[Category: Cuff, M E.]]

[[Category: Joachimiak, A.]]

[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]

[[Category: MCSG, Midwest Center for Structural Genomics.]]

[[Category: Zhou, M.]]

[[Category: hemolysin-corregulation]]

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[[Category: structural genomics]]

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@@ Line 1: / Line 1: @@
-[[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1y12, resolution 1.95&Aring;" />
 '''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''<br />
 ==Overview==
-Bacterial pathogens frequently use protein secretion to mediate, interactions with their hosts. Here we found that a virulence locus, (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus., The apparatus assembled in discrete subcellular locations and exported, Hcp1, a hexameric protein that forms rings with a 40 angstrom internal, diameter. Regulatory patterns of HSI-I suggested that the apparatus, functions during chronic infections. We detected Hcp1 in pulmonary, secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies, in their sera. Thus, HSI-I likely contributes to the pathogenesis of P., aeruginosa in CF patients. HSI-I-related loci are widely distributed among, bacterial pathogens and may play a general role in mediating host, interactions.
+Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
 ==About this Structure==
-Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA].
+Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Pseudomonas aeruginosa]]
 [[Category: Single protein]]
-[[Category: Cuff, M.E.]]
+[[Category: Cuff, M E.]]
 [[Category: Joachimiak, A.]]
-[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
+[[Category: MCSG, Midwest Center for Structural Genomics.]]
 [[Category: Zhou, M.]]
 [[Category: hemolysin-corregulation]]
@@ Line 25: / Line 25: @@
 [[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:29:04 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:00:43 2008''