1ya3: Difference between revisions

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[[Image:1ya3.gif|left|200px]]<br />

[[Image:1ya3.gif|left|200px]]<br /><applet load="1ya3" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ya3" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ya3, resolution 2.34Å" />

'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''<br />

==Overview==

The S810L mutation within the human mineralocorticoid receptor (MR S810L), induces severe hypertension and switches progesterone from antagonist to, agonist. Here we report the crystal structures of the ligand-binding, domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first, for MR, identify the specific contacts created by Leu810 and clarify the, mechanism of activation of MR S810L.

The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.

==Disease==

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==About this Structure==

1YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with STR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1YA3 OCA].

1YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STR:'>STR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA3 OCA].

==Reference==

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[[Category: Huyet, J.]]

[[Category: Mayer, C.]]

[[Category: Pinon, G.M.]]

[[Category: Pinon, G M.]]

[[Category: Rafestin-Oblin, M.E.]]

[[Category: Rafestin-Oblin, M E.]]

[[Category: Rochel, M.]]

[[Category: STR]]

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[[Category: steroid receptor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:16:~~55 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:03:13 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ya3.gif|left|200px]]<br />
+[[Image:1ya3.gif|left|200px]]<br /><applet load="1ya3" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ya3" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ya3, resolution 2.34&Aring;" />
 '''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''<br />
 ==Overview==
-The S810L mutation within the human mineralocorticoid receptor (MR S810L), induces severe hypertension and switches progesterone from antagonist to, agonist. Here we report the crystal structures of the ligand-binding, domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first, for MR, identify the specific contacts created by Leu810 and clarify the, mechanism of activation of MR S810L.
+The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with STR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YA3 OCA].
+YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STR:'>STR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA3 OCA].
 ==Reference==
@@ Line 20: / Line 19: @@
 [[Category: Huyet, J.]]
 [[Category: Mayer, C.]]
-[[Category: Pinon, G.M.]]
+[[Category: Pinon, G M.]]
-[[Category: Rafestin-Oblin, M.E.]]
+[[Category: Rafestin-Oblin, M E.]]
 [[Category: Rochel, M.]]
 [[Category: STR]]
@@ Line 30: / Line 29: @@
 [[Category: steroid receptor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:16:55 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:03:13 2008''