3e8d: Difference between revisions

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{{Seed}}
[[Image:3e8d.png|left|200px]]
[[Image:3e8d.png|left|200px]]


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{{STRUCTURE_3e8d|  PDB=3e8d  |  SCENE=  }}  
{{STRUCTURE_3e8d|  PDB=3e8d  |  SCENE=  }}  


===Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors===
===Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors===


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{{ABSTRACT_PUBMED_19179070}}
{{ABSTRACT_PUBMED_19179070}}
==Disease==
Known disease associated with this structure: Diabetes mellitus, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164731 164731]]


==About this Structure==
==About this Structure==
3E8D is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E8D OCA].  
[[3e8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E8D OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19179070</ref><references group="xtra"/>
<ref group="xtra">PMID:019179070</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Ward, P.]]
[[Category: Ward, P.]]
[[Category: Akt2]]
[[Category: Akt2]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Gsk3 beta]]
[[Category: Gsk3 beta]]
Line 40: Line 24:
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Wnt signaling pathway]]
[[Category: Wnt signaling pathway]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:29:51 2009''

Revision as of 08:36, 9 January 2013

File:3e8d.png

Template:STRUCTURE 3e8d

Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors

Template:ABSTRACT PUBMED 19179070

About this Structure

3e8d is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Rouse MB, Seefeld MA, Leber JD, McNulty KC, Sun L, Miller WH, Zhang S, Minthorn EA, Concha NO, Choudhry AE, Schaber MD, Heerding DA. Aminofurazans as potent inhibitors of AKT kinase. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1508-11. Epub 2009 Jan 9. PMID:19179070 doi:10.1016/j.bmcl.2009.01.002

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