1yok: Difference between revisions

[[Image:1yok.gif|left|200px]]<br /><applet load="1yok" size="350" color="white" frame="true" align="right" spinBox="true"  

Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.

1YOK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=P6L:'>P6L</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOK OCA].  

[[Category: Bynum, J M.]]

[[Category: Fletterick, R J.]]

[[Category: Guy, R K.]]

[[Category: Ingraham, H A.]]

[[Category: Krylova, I N.]]

[[Category: MacKay, J A.]]

[[Category: Sablin, E P.]]

[[Category: Thornton, J W.]]

[[Category: Waitt, G M.]]

[[Category: Williams, J D.]]

[[Category: Williams, S P.]]

[[Category: Willson, T M.]]

[[Category: Xu, R X.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:27 2008''