1yt9: Difference between revisions
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==Overview== | ==Overview== | ||
The need for a potent HIV protease inhibitor (PI) to combat emerging | The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dekhtyar, T.]] | [[Category: Dekhtyar, T.]] | ||
[[Category: Flentge, C | [[Category: Flentge, C A.]] | ||
[[Category: Kempf, D | [[Category: Kempf, D J.]] | ||
[[Category: Klein, L | [[Category: Klein, L L.]] | ||
[[Category: Randolph, J | [[Category: Randolph, J T.]] | ||
[[Category: Stoll, V | [[Category: Stoll, V S.]] | ||
[[Category: Sun, M.]] | [[Category: Sun, M.]] | ||
[[Category: Yeung, C | [[Category: Yeung, C M.]] | ||
[[Category: Zhao, C.]] | [[Category: Zhao, C.]] | ||
[[Category: OIS]] | [[Category: OIS]] | ||
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[[Category: oximinoarylsulfonamides]] | [[Category: oximinoarylsulfonamides]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:08:54 2008'' | ||
