1yw2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="1yw2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yw2, resolution 2.01Å" /> '''Mutated Mus Musculus... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1yw2.gif|left|200px]]<br /><applet load="1yw2" size=" | [[Image:1yw2.gif|left|200px]]<br /><applet load="1yw2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1yw2, resolution 2.01Å" /> | caption="1yw2, resolution 2.01Å" /> | ||
'''Mutated Mus Musculus P38 Kinase (mP38)'''<br /> | '''Mutated Mus Musculus P38 Kinase (mP38)'''<br /> | ||
==Overview== | ==Overview== | ||
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis | 4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production. | ||
==About this Structure== | ==About this Structure== | ||
1YW2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with PGJ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 1YW2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=PGJ:'>PGJ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YW2 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bookland, R | [[Category: Bookland, R G.]] | ||
[[Category: Brugel, T | [[Category: Brugel, T A.]] | ||
[[Category: Clark, M | [[Category: Clark, M P.]] | ||
[[Category: De, B.]] | [[Category: De, B.]] | ||
[[Category: Djung, J | [[Category: Djung, J F.]] | ||
[[Category: Golebiowski, A.]] | [[Category: Golebiowski, A.]] | ||
[[Category: Hsieh, L | [[Category: Hsieh, L C.]] | ||
[[Category: Janusz, M | [[Category: Janusz, M J.]] | ||
[[Category: Laufersweiler, M | [[Category: Laufersweiler, M J.]] | ||
[[Category: Laughlin, S | [[Category: Laughlin, S K.]] | ||
[[Category: Mekel, M | [[Category: Mekel, M J.]] | ||
[[Category: Sabat, M.]] | [[Category: Sabat, M.]] | ||
[[Category: Townes, J | [[Category: Townes, J A.]] | ||
[[Category: Vanrens, J | [[Category: Vanrens, J C.]] | ||
[[Category: Walter, R | [[Category: Walter, R L.]] | ||
[[Category: Xu, S | [[Category: Xu, S C.]] | ||
[[Category: PGJ]] | [[Category: PGJ]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:47 2008'' | ||
