Cytochrome P450: Difference between revisions

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== 3D Structures of Cytochrome P450  ==
== 3D Structures of Cytochrome P450  ==


''Updated June 2012''
''Updated January 2013''


=== human P450 1 family ===
=== human P450 1 family ===
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[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
[[1z10]] - hP4502A6 catalytic domain+coumarin<br />
[[1z10]] - hP4502A6 catalytic domain+coumarin<br />
[[4ejj]] - hP4502A6 + nicotine<br />
[[3t3q]], [[3t3r]] - hP4502A6 (mutant) + pilocarpine<br />
[[3t3q]], [[3t3r]] - hP4502A6 (mutant) + pilocarpine<br />
[[2z10]] – hP4502A6+coumarin<br />
[[2z10]] – hP4502A6+coumarin<br />
[[1z11]] - hP4502A6+methoxalen<br />
[[1z11]] - hP4502A6+methoxalen<br />
[[3t3r]] - hP4502A13 + pilocarpine<br />
[[3t3s]] - hP4502A13 + pilocarpine<br />
[[4ejg]] - hP4502A13 + nicotine<br />
[[4ejh]], [[4eji]] - hP4502A13 + pyridine derivative<BR />
[[2p85]] – hP4502A13 (mutant)+indole<br />
[[2p85]] – hP4502A13 (mutant)+indole<br />
[[3tk3]] - hP4502B4 (mutant) + imidazole derivative<br />
[[3tk3]] - hP4502B4 (mutant) + imidazole derivative<br />
[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
[[2nnh]] – hP4502C8+retinoic acid<br />
[[2nnh]] – hP4502C8+retinoic acid<br />
[[2nni]] - hP4502C8+montelukast<br />
[[2nni]] - hP4502C8+montelukast<br />
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[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
[[4gqs]] - hP4502C19 catalytic domain<br />
[[2f9q]], [[3qm4]] – hP4502D6<br />
[[2f9q]], [[3qm4]] – hP4502D6<br />
[[3tbg]] – hP4502D6 + thioridazine<br />
[[3tda]] – hP4502D6 + prinomastat<br />
[[3gph]], [[3koh]], [[3lc4]]  – hP4502E1 fragment +imidazole derivative<br />  
[[3gph]], [[3koh]], [[3lc4]]  – hP4502E1 fragment +imidazole derivative<br />  
[[3e6i]] – hP4502E1 fragment+indazole<br />
[[3e6i]] – hP4502E1 fragment+indazole<br />
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[[3ua1]] - hP4503A4 + ergocryptine<br />
[[3ua1]] - hP4503A4 + ergocryptine<br />
[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />


=== human P450 7 family ===
=== human P450 7 family ===
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=== human P450 19 family ===
=== human P450 19 family ===


[[3eqm]] - hP45019A1+androstenedione
[[3eqm]], [[3s79]] - hP45019A1+androstenedione<br />
 
[[3s7s]] - hP45019A1 + exemestane<br />
[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor


=== human P450 46 family ===
=== human P450 46 family ===
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[[2vn0]] – hP450105A1+troglitazone<br />
[[2vn0]] – hP450105A1+troglitazone<br />
[[2zby]] - hP450105A1 (mutant)
[[2zby]] - hP450105A1 (mutant)


=== P450 from  ''Mycobacterium tuberculosis'' ===
=== P450 from  ''Mycobacterium tuberculosis'' ===
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[[2ij7]] - MtP450121+fluconazole<br />
[[2ij7]] - MtP450121+fluconazole<br />
[[1n4g]] - MtP450121+iodopyrazole<br />
[[1n4g]] - MtP450121+iodopyrazole<br />
[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]] - MtP450121 + inhibitor<br />
[[3ivi]], [[3iw0]], [[3ivy]] – MtP450125 <br />
[[3ivi]], [[3iw0]], [[3ivy]] – MtP450125 <br />
[[3iw1]] - MtP450125+androstenedione<br />
[[3iw1]] - MtP450125+androstenedione<br />
Line 109: Line 116:
[[2w09]], [[2w0b]], [[2w0a]] - MtP450130 (mutant)+pyridine inhibitor<br />
[[2w09]], [[2w0b]], [[2w0a]] - MtP450130 (mutant)+pyridine inhibitor<br />
[[2uuq]] – MtP450130
[[2uuq]] – MtP450130


=== P450cam ===
=== P450cam ===


[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]]– PpP450cam(mutant) – ''Pseudomona putida''<br />
[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]],[[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]] – PpP450cam(mutant) – ''Pseudomona putida''<br />
[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]] - PpP450cam<br />
[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]] - PpP450cam<br />
[[2qbo]] - PpP450cam (mutant)+cyanide<br />
[[2qbo]] - PpP450cam (mutant)+cyanide<br />
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[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
[[2l8m]] – PpP450cam+camphor+CO<br />
[[2l8m]] – PpP450cam+camphor+CO<br />
[[4g3r]] – PpP450cam+camphor+NO<br />
[[2fe6]], [[2fer]], [[2feu]] - PpP450cam+Mn protoporphyrin IX<br />
[[2fe6]], [[2fer]], [[2feu]] - PpP450cam+Mn protoporphyrin IX<br />
[[1uyu]] - PpP450cam+ Xe<br />
[[1uyu]] - PpP450cam+ Xe<br />
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[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]] - PpP450cam (mutant)+substrate analog<br />
[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]] - PpP450cam (mutant)+substrate analog<br />


=== P450nor ===
=== P450nor ===
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[[2bdm]] – rP4502B4 – rabbit<br />
[[2bdm]] – rP4502B4 – rabbit<br />
[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]] -  rP4502B4 (mutant)<br />
[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]] -  rP4502B4 (mutant)<br />
[[1suo]] - rP4502B4 (mutant)+imidazole<br />
[[1suo]],[[3g5n]], [[3g93]], [[2q6n]] - rP4502B4 (mutant)+imidazole derivative<br />
[[3kw4]], [[3me6]] - rP4502B4 (mutant)+anti-platelet drug<br />
[[3kw4]], [[3me6]], [[3tmz]] - rP4502B4 (mutant)+anti-platelet drug<br />
[[1dt6]] - rP4502C5 (mutant)<br />
[[1dt6]] - rP4502C5 (mutant)<br />
[[1nr6]] – rP4502C5+diclofenac<br />
[[1nr6]] – rP4502C5+diclofenac<br />
[[1n6b]] - rP4502C5+sulfaphenazole
[[1n6b]] - rP4502C5+sulfaphenazole


===Bifunctional P450/NADPH P450 reductase===
[[3cbd – BmP450 domain – ''Bacillus megaterium''<br />
[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]] - BmP450 domain (mutant)<br />
[[4dtw]], [[4due]], [[4duf]] - BmP450 domain (mutant) + serotonin<br />
[[4dtz]], [[4du2]], [[4dub]] - BmP450 domain (mutant) + dopamine


=== Other CYPs ===
=== Other CYPs ===
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[[2z3t]] - SsP450245A1<br />
[[2z3t]] - SsP450245A1<br />
[[2z3u]] - SsP450245A1+chromopyrrolic acid<br />
[[2z3u]] - SsP450245A1+chromopyrrolic acid<br />
[[3g5n]], [[3g93]] – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit<br />
[[2q6n]] – rP4502B4 (mutant)+chlorophenyl-imidazole<br />
[[3cv8]] – SgP450105A1 (mutant) – ''Streptomyces griseolus''<br />
[[3cv8]] – SgP450105A1 (mutant) – ''Streptomyces griseolus''<br />
[[3cv9]], [[2zbz]] - SgP450105A1 (mutant)+vitamin D3<br />
[[3cv9]], [[2zbz]] - SgP450105A1 (mutant)+vitamin D3<br />
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[[1n97]] – TtP450175A1<br />
[[1n97]] – TtP450175A1<br />
[[3lxh]], [[3lxi]], [[3ofu]] – NaP240101D1 – ''Novosphingobium aromaticivorans''<br />
[[3lxh]], [[3lxi]], [[3ofu]] – NaP240101D1 – ''Novosphingobium aromaticivorans''<br />
[[3nv5]], [[3nv6]] - NaP240101D2<br />
[[3nv5]], [[3nv6]], [[4dxy]] - NaP240101D2<br />
[[3tkt]] – NaP450108D1<br />
[[3tkt]] – NaP450108D1<br />
[[3awm]] – SpP450-α + palmitic acid – ''Sphingomonas paucimobilis''<br />
[[3awm]] – SpP450-α + palmitic acid – ''Sphingomonas paucimobilis''<br />
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[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
[[3a4z]] - PaP450 VDH (mutant)<br />
[[3a4z]] - PaP450 VDH (mutant)<br />
[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3
[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
[[3qi8]] – P450 – synthetic<br />
[[4dnz]] – RpP450 – ''Rhodopseudomonas palustris''<br />
[[4do1]] – RpP450 + methoxybenzoate
 


[[Category:Topic Page]]
[[Category:Topic Page]]
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