1z92: Difference between revisions

[[Image:1z92.gif|left|200px]]<br /><applet load="1z92" size="350" color="white" frame="true" align="right" spinBox="true"  

Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.

Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]]

1Z92 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA].  

[[Category: Boulanger, M J.]]

[[Category: Garcia, K C.]]

[[Category: Wang, X Q.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:14 2008''