1zbj: Difference between revisions

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[[Image:1zbj.gif|left|200px]]<br />

[[Image:1zbj.gif|left|200px]]<br /><applet load="1zbj" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1zbj" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1zbj" />

'''Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein'''<br />

==Overview==

Macromolecular structures calculated from nuclear magnetic resonance data, are not fully determined by experimental data but depend on subjective, choices in data treatment and parameter settings. This makes it difficult, to objectively judge the precision of the structures. We used Bayesian, inference to derive a probability distribution that represents the unknown, structure and its precision. This probability distribution also determines, additional unknowns, such as theory parameters, that previously had to be, chosen empirically. We implemented this approach by using Markov chain, Monte Carlo techniques. Our method provides an objective figure of merit, and improves structural quality.

Macromolecular structures calculated from nuclear magnetic resonance data are not fully determined by experimental data but depend on subjective choices in data treatment and parameter settings. This makes it difficult to objectively judge the precision of the structures. We used Bayesian inference to derive a probability distribution that represents the unknown structure and its precision. This probability distribution also determines additional unknowns, such as theory parameters, that previously had to be chosen empirically. We implemented this approach by using Markov chain Monte Carlo techniques. Our method provides an objective figure of merit and improves structural quality.

==About this Structure==

1ZBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1ZBJ OCA].

1ZBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBJ OCA].

==Reference==

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[[Category: transferase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:32:~~01 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:57 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1zbj.gif|left|200px]]<br />
+[[Image:1zbj.gif|left|200px]]<br /><applet load="1zbj" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1zbj" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1zbj" />
 '''Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein'''<br />
 ==Overview==
-Macromolecular structures calculated from nuclear magnetic resonance data, are not fully determined by experimental data but depend on subjective, choices in data treatment and parameter settings. This makes it difficult, to objectively judge the precision of the structures. We used Bayesian, inference to derive a probability distribution that represents the unknown, structure and its precision. This probability distribution also determines, additional unknowns, such as theory parameters, that previously had to be, chosen empirically. We implemented this approach by using Markov chain, Monte Carlo techniques. Our method provides an objective figure of merit, and improves structural quality.
+Macromolecular structures calculated from nuclear magnetic resonance data are not fully determined by experimental data but depend on subjective choices in data treatment and parameter settings. This makes it difficult to objectively judge the precision of the structures. We used Bayesian inference to derive a probability distribution that represents the unknown structure and its precision. This probability distribution also determines additional unknowns, such as theory parameters, that previously had to be chosen empirically. We implemented this approach by using Markov chain Monte Carlo techniques. Our method provides an objective figure of merit and improves structural quality.
 ==About this Structure==
-ZBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZBJ OCA].
+ZBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBJ OCA].
 ==Reference==
@@ Line 20: / Line 19: @@
 [[Category: transferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:32:01 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:57 2008''