2vwy: Difference between revisions

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[[Image:2vwy.png|left|200px]]
[[Image:2vwy.png|left|200px]]


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{{STRUCTURE_2vwy|  PDB=2vwy  |  SCENE=  }}  
{{STRUCTURE_2vwy|  PDB=2vwy  |  SCENE=  }}  


===EPHB4 KINASE DOMAIN INHIBITOR COMPLEX===
===EPHB4 KINASE DOMAIN INHIBITOR COMPLEX===


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{{ABSTRACT_PUBMED_18851911}}
{{ABSTRACT_PUBMED_18851911}}


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==Reference==
==Reference==
<ref group="xtra">PMID:18851911</ref><ref group="xtra">PMID:18434142</ref><references group="xtra"/>
<ref group="xtra">PMID:018851911</ref><ref group="xtra">PMID:018434142</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Receptor tyrosine kinase]]
[[Category: Receptor tyrosine kinase]]

Revision as of 12:54, 30 January 2013

File:2vwy.png

Template:STRUCTURE 2vwy

EPHB4 KINASE DOMAIN INHIBITOR COMPLEX

Template:ABSTRACT PUBMED 18851911

About this Structure

2vwy is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5717-21. Epub 2008 Sep 27. PMID:18851911 doi:10.1016/j.bmcl.2008.09.087
  2. Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines. Bioorg Med Chem Lett. 2008 May 1;18(9):2776-80. Epub 2008 Apr 10. PMID:18434142 doi:10.1016/j.bmcl.2008.04.015

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