Group:MUZIC:ALP: Difference between revisions
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== Structures == | == Structures == | ||
Molecular structures of the PDZ or LIM domains of protein members of this subfamily are known; both in their apo forms and where presented, in complex with the C-terminal extension of their binding partners. These structures present insightful features highlighting their respective interactions and functions. In particular, the recent crystal structure of the PDZ domain of human mystique (PDLIM2) in complex with the highly pathogenic avian flu | Molecular structures of the PDZ or LIM domains of protein members of this subfamily are known; both in their apo forms and where presented, in complex with the C-terminal extension of their binding partners. These structures present insightful features highlighting their respective interactions and functions. In particular, the recent crystal structure of the PDZ domain of human mystique (PDLIM2) in complex with the highly pathogenic avian flu viral particle (the PDZ-binding motif), shows structural mechanism of binding with atomic specificity <ref name="e">doi:10.1371/journal.pone.0019511</ref>. The structures for PDZ and LIM domains from human ALP (PDLIM3) are presently unknown, however the solution structures of both the PDZ and LIM domains of ALP from mouse have been solved. | ||
<Structure load='2PKT' size='150' frame='true' align='right' caption='X-ray crystal structure of the PDZ domain of human hCLIM1 (PDB code: 2PKT)[http://www.pdb.org/pdb/explore/explore.do?structureId=2PKT]'/> | <Structure load='2PKT' size='150' frame='true' align='right' caption='X-ray crystal structure of the PDZ domain of human hCLIM1 in complex with the C-terminal peptide of α-actinin-1 (PDB code: 2PKT)[http://www.pdb.org/pdb/explore/explore.do?structureId=2PKT]'/> | ||
<Structure load='3PDV' size='150' frame='true' align='right' caption='X-ray crystal structure of the PDZ domain of human PDLIM2 in complex with pathogenic bird flu | <Structure load='3PDV' size='150' frame='true' align='right' caption='X-ray crystal structure of the PDZ domain of human PDLIM2 in complex with pathogenic bird flu viral peptide NS1 (PDB code: 3PDV)[http://www.pdb.org/pdb/explore/explore.do?structureId=3PDV]'/> | ||
<Structure load='1X64' size='150' frame='true' align='right' caption='NMR solution structure of the LIM domain of mouse PDLIM3(ALP)(PDB code: 1X64)[http://www.pdb.org/pdb/explore/explore.do?structureId=1X64]'/> | <Structure load='1X64' size='150' frame='true' align='right' caption='NMR solution structure of the LIM domain of mouse PDLIM3(ALP)(PDB code: 1X64)[http://www.pdb.org/pdb/explore/explore.do?structureId=1X64]'/> | ||
<Structure load='1v51' size='150' frame='true' align='right' caption='NMR solution structure of the PDZ domain of mouse PDLIM3(ALP)(PDB code: 1v51)[http://www.rcsb.org/pdb/explore/explore.do?pdbId=1v5l]'/> | <Structure load='1v51' size='150' frame='true' align='right' caption='NMR solution structure of the PDZ domain of mouse PDLIM3(ALP)(PDB code: 1v51)[http://www.rcsb.org/pdb/explore/explore.do?pdbId=1v5l]'/> | ||
<Structure load='2V1W' size='150' frame='true' align='right' caption='X-ray crystal stucture of the PDZ domain of human PDLIM4 (RIL) in complex with human α-actinin-1(PDB code: 2V1W)[http://www.rcsb.org/pdb/explore/explore.do?structureId=2V1W]'/> | <Structure load='2V1W' size='150' frame='true' align='right' caption='X-ray crystal stucture of the PDZ domain of human PDLIM4 (RIL) in complex with human α-actinin-1(PDB code: 2V1W)[http://www.rcsb.org/pdb/explore/explore.do?structureId=2V1W]'/> | ||
==Function and Interactions== | ==Function and Interactions== | ||
