Group:MUZIC:Plectin: Difference between revisions
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== Introduction == | == Introduction == | ||
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'''1. Actin Binding Domain (ABD)''' | '''1. Actin Binding Domain (ABD)''' | ||
<Structure load='1sh6' size='300' frame='true' align='right' caption='The actin binding domain of plectin (PDB:1SH6)' scene='User:Jae-Geun_Song/Workbench/plectin/Plecin_actin_binding_domain/1'/> | |||
Plectin has a canonical actin binding domain in N-terminus, which is consisted of two calponin homology domain(<scene name='User:Jae-Geun_Song/Workbench/plectin/Plecin_actin_binding_domain/3'>CH1 and CH2</scene>)<ref>PMID:9164454</ref>. N-terminal domain of plectin containing ABD interacts with F-actin and regulates actin dynamics in vivo, additionally binding of plectin ABD to vimentin was also reported <ref>PMID: 15128297</ref>. | Plectin has a canonical actin binding domain in N-terminus, which is consisted of two calponin homology domain(<scene name='User:Jae-Geun_Song/Workbench/plectin/Plecin_actin_binding_domain/3'>CH1 and CH2</scene>)<ref>PMID:9164454</ref>. N-terminal domain of plectin containing ABD interacts with F-actin and regulates actin dynamics in vivo, additionally binding of plectin ABD to vimentin was also reported <ref>PMID: 15128297</ref>. | ||
