1zpi: Difference between revisions
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New page: left|200px<br /><applet load="1zpi" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zpi, resolution 1.60Å" /> '''Crystal structure an... |
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==Overview== | ==Overview== | ||
The structures of the complexes formed between two anticancer | The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Adams, A.]] | [[Category: Adams, A.]] | ||
[[Category: Denny, W | [[Category: Denny, W A.]] | ||
[[Category: Guss, J | [[Category: Guss, J M.]] | ||
[[Category: Leong, C.]] | [[Category: Leong, C.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: minor groove binding complex]] | [[Category: minor groove binding complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:51 2008'' | ||
