Potassium Channel: Difference between revisions
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== 3D structures of Potassium Channels== | == 3D structures of Potassium Channels== | ||
''Update | ''Update February 2013'' | ||
'''Potassium channels''' (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | '''Potassium channels''' (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | ||
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[[1jq1]], [[1jq2]] - SlKCh inner transmembrane segment - NMR<br /> | [[1jq1]], [[1jq2]] - SlKCh inner transmembrane segment - NMR<br /> | ||
[[3ifx]] - SlKCh pore domain<br /> | [[3ifx]] - SlKCh pore domain<br /> | ||
[[3pjs]] – SlKCh + antibody<br /> | |||
[[2pnv]] – rKCh leucine zipper domain SKCa – rat<br /> | [[2pnv]] – rKCh leucine zipper domain SKCa – rat<br /> | ||
[[3lut]] - rKCh Kv1.2 (mutant) <br /> | [[3lut]] - rKCh Kv1.2 (mutant) <br /> | ||
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[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain - ''Methanobacterium thermoautrophicum''<br /> | [[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain - ''Methanobacterium thermoautrophicum''<br /> | ||
[[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | [[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | ||
[[2aef]], [[3kxd]] - MthK RCK domain + Ca<br /> | [[2aef]], [[3kxd]], [[4ei2]] - MthK RCK domain + Ca<br /> | ||
[[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca<br /> | [[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca<br /> | ||
[[3r65]] – MthK pore domain (mutant) | [[3r65]], [[4hyo]], [[4hz3]] – MthK pore domain (mutant) | ||
===Large conductance calcium-activated KCh=== | ===Large conductance calcium-activated KCh=== | ||
