Prion: Difference between revisions

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[[Image:3haf.png|left|200px|thumb|Crystal Structure of human prion [[3haf]]]]
[[Image:3haf.png|left|200px|thumb|Crystal Structure of human prion [[3haf]]]]
{{STRUCTURE_3haf|  PDB=3haf  | SIZE=400| SCENE=Prion/Cv/3 |right|CAPTION=human prion domain swapped dimer complex with Cd and Cl ions [[3haf]] }}
{{STRUCTURE_3haf|  PDB=3haf  | SIZE=400| SCENE=Prion/Cv/3 |right|CAPTION=human prion domain swapped dimer complex with Cd and Cl ions [[3haf]] }}
{{STRUCTURE_2w9e|  PDB=2w9e  | SIZE=400| SCENE= |right|CAPTION=human prion PRP (grey) with FAB heavy chain (rust) and light chain (green) complex with sulfate [[2w9e]] }}
'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation.  The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies.  Yeast prion proteins are Sup35 and Ure2.  The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[3haf]]). For more details see [[Prion protein]]. Click here to see <scene name='Prion/Cv/2'>example of prion unfolding</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).  
'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation.  The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies.  Yeast prion proteins are Sup35 and Ure2.  The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[3haf]]). For more details see [[Prion protein]]. Click here to see <scene name='Prion/Cv/2'>example of prion unfolding</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).  


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