2ah0: Difference between revisions

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==Overview==

We present an atomic-level description of the reaction chemistry of an, enzyme-catalyzed reaction dominated by proton tunneling. By solving, structures of reaction intermediates at near-atomic resolution, we have, identified the reaction pathway for tryptamine oxidation by aromatic amine, dehydrogenase. Combining experiment and computer simulation, we show, proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a, reaction dominated by tunneling over approximately 0.6 angstroms. The role, of long-range coupled motions in promoting tunneling is controversial. We, show that, in this enzyme system, tunneling is promoted by a short-range, motion modulating proton-acceptor distance and no long-range coupled, motion is required.

We present an atomic-level description of the reaction chemistry of an enzyme-catalyzed reaction dominated by proton tunneling. By solving structures of reaction intermediates at near-atomic resolution, we have identified the reaction pathway for tryptamine oxidation by aromatic amine dehydrogenase. Combining experiment and computer simulation, we show proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a reaction dominated by tunneling over approximately 0.6 angstroms. The role of long-range coupled motions in promoting tunneling is controversial. We show that, in this enzyme system, tunneling is promoted by a short-range motion modulating proton-acceptor distance and no long-range coupled motion is required.

==About this Structure==

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[[Category: Basran, J.]]

[[Category: Hothi, P.]]

[[Category: Johannissen, L.O.]]

[[Category: Johannissen, L O.]]

[[Category: Leys, D.]]

[[Category: Masgrau, L.]]

[[Category: Mulholland, A.J.]]

[[Category: Mulholland, A J.]]

[[Category: Ranaghan, K.E.]]

[[Category: Ranaghan, K E.]]

[[Category: Roujeinikova, A.]]

[[Category: Scrutton, N.S.]]

[[Category: Scrutton, N S.]]

[[Category: Sutcliffe, M.J.]]

[[Category: Sutcliffe, M J.]]

[[Category: TSC]]

[[Category: TSH]]

[[Category: oxidoreductase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:27:18 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-We present an atomic-level description of the reaction chemistry of an, enzyme-catalyzed reaction dominated by proton tunneling. By solving, structures of reaction intermediates at near-atomic resolution, we have, identified the reaction pathway for tryptamine oxidation by aromatic amine, dehydrogenase. Combining experiment and computer simulation, we show, proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a, reaction dominated by tunneling over approximately 0.6 angstroms. The role, of long-range coupled motions in promoting tunneling is controversial. We, show that, in this enzyme system, tunneling is promoted by a short-range, motion modulating proton-acceptor distance and no long-range coupled, motion is required.
+We present an atomic-level description of the reaction chemistry of an enzyme-catalyzed reaction dominated by proton tunneling. By solving structures of reaction intermediates at near-atomic resolution, we have identified the reaction pathway for tryptamine oxidation by aromatic amine dehydrogenase. Combining experiment and computer simulation, we show proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a reaction dominated by tunneling over approximately 0.6 angstroms. The role of long-range coupled motions in promoting tunneling is controversial. We show that, in this enzyme system, tunneling is promoted by a short-range motion modulating proton-acceptor distance and no long-range coupled motion is required.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Basran, J.]]
 [[Category: Hothi, P.]]
-[[Category: Johannissen, L.O.]]
+[[Category: Johannissen, L O.]]
 [[Category: Leys, D.]]
 [[Category: Masgrau, L.]]
-[[Category: Mulholland, A.J.]]
+[[Category: Mulholland, A J.]]
-[[Category: Ranaghan, K.E.]]
+[[Category: Ranaghan, K E.]]
 [[Category: Roujeinikova, A.]]
-[[Category: Scrutton, N.S.]]
+[[Category: Scrutton, N S.]]
-[[Category: Sutcliffe, M.J.]]
+[[Category: Sutcliffe, M J.]]
 [[Category: TSC]]
 [[Category: TSH]]
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:01:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:27:18 2008''