2alv: Difference between revisions
New page: left|200px<br /><applet load="2alv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2alv, resolution 1.90Å" /> '''X-ray structural ana... |
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==Overview== | ==Overview== | ||
Design, synthesis, and biological evaluation of peptidomimetic severe | Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Baker, S | [[Category: Baker, S C.]] | ||
[[Category: Fu, W.]] | [[Category: Fu, W.]] | ||
[[Category: Ghosh, A | [[Category: Ghosh, A K.]] | ||
[[Category: Harcourt, B | [[Category: Harcourt, B H.]] | ||
[[Category: Johnson, M | [[Category: Johnson, M E.]] | ||
[[Category: Mesecar, A | [[Category: Mesecar, A D.]] | ||
[[Category: Ratia, K.]] | [[Category: Ratia, K.]] | ||
[[Category: Rota, P | [[Category: Rota, P A.]] | ||
[[Category: Santarsiero, B | [[Category: Santarsiero, B D.]] | ||
[[Category: Xi, K.]] | [[Category: Xi, K.]] | ||
[[Category: CY6]] | [[Category: CY6]] | ||
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[[Category: sars]] | [[Category: sars]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:39 2008'' | ||
Revision as of 14:28, 21 February 2008
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X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus with CY6 as ligand. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632
Page seeded by OCA on Thu Feb 21 16:28:39 2008
