2ao7: Difference between revisions
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New page: left|200px<br /><applet load="2ao7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ao7, resolution 2.9Å" /> '''Adam10 Disintegrin an... |
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[[Image:2ao7.gif|left|200px]]<br /><applet load="2ao7" size=" | [[Image:2ao7.gif|left|200px]]<br /><applet load="2ao7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2ao7, resolution 2.9Å" /> | caption="2ao7, resolution 2.9Å" /> | ||
'''Adam10 Disintegrin and cysteine- rich domain'''<br /> | '''Adam10 Disintegrin and cysteine- rich domain'''<br /> | ||
==Overview== | ==Overview== | ||
Ephrin ligands presented on one cell surface associate with their | Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease. | ||
==About this Structure== | ==About this Structure== | ||
2AO7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/ADAM10_endopeptidase ADAM10 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.81 3.4.24.81] Full crystallographic information is available from [http:// | 2AO7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/ADAM10_endopeptidase ADAM10 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.81 3.4.24.81] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AO7 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barton, W | [[Category: Barton, W A.]] | ||
[[Category: Blobel, C | [[Category: Blobel, C P.]] | ||
[[Category: Himanen, J | [[Category: Himanen, J P.]] | ||
[[Category: Janes, P | [[Category: Janes, P W.]] | ||
[[Category: Kolev, M | [[Category: Kolev, M V.]] | ||
[[Category: Lackmann, M.]] | [[Category: Lackmann, M.]] | ||
[[Category: Nievergall, E.]] | [[Category: Nievergall, E.]] | ||
[[Category: Nikolov, D | [[Category: Nikolov, D B.]] | ||
[[Category: Saha, N.]] | [[Category: Saha, N.]] | ||
[[Category: Wimmer-Kleikamp, S | [[Category: Wimmer-Kleikamp, S H.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: disintegrin]] | [[Category: disintegrin]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:29:19 2008'' | ||
Revision as of 14:29, 21 February 2008
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Adam10 Disintegrin and cysteine- rich domain
Overview
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
About this Structure
2AO7 is a Single protein structure of sequence from Bos taurus with SO4 as ligand. Active as ADAM10 endopeptidase, with EC number 3.4.24.81 Full crystallographic information is available from OCA.
Reference
ADAM and Eph: how Ephrin-signaling cells become detached., Mancia F, Shapiro L, Cell. 2005 Oct 21;123(2):185-7. PMID:16239135
Page seeded by OCA on Thu Feb 21 16:29:19 2008
