3d0e: Difference between revisions

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[[Image:3d0e.png|left|200px]]
[[Image:3d0e.png|left|200px]]


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{{STRUCTURE_3d0e|  PDB=3d0e  |  SCENE=  }}  
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===Crystal structure of human Akt2 in complex with GSK690693===
===Crystal structure of human Akt2 in complex with GSK690693===


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{{ABSTRACT_PUBMED_18800763}}


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==Reference==
==Reference==
<ref group="xtra">PMID:18800763</ref><references group="xtra"/>
<ref group="xtra">PMID:018800763</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Concha, N O.]]
[[Category: Concha, N O.]]
[[Category: Smallwood, A.]]
[[Category: Smallwood, A.]]
[[Category: Akt2]]
[[Category: Atp-binding]]
[[Category: Human]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase inhibitor]]

Revision as of 15:42, 27 February 2013

File:3d0e.png

Template:STRUCTURE 3d0e

Crystal structure of human Akt2 in complex with GSK690693

Template:ABSTRACT PUBMED 18800763

About this Structure

3d0e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]o xy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem. 2008 Sep 25;51(18):5663-79. PMID:18800763 doi:10.1021/jm8004527

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