2b1p: Difference between revisions
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==Overview== | ==Overview== | ||
The structure-based design and synthesis of a new series of c-Jun | The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site. | ||
==Disease== | ==Disease== | ||
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[[Category: Malmstrom, J.]] | [[Category: Malmstrom, J.]] | ||
[[Category: Ohberg, L.]] | [[Category: Ohberg, L.]] | ||
[[Category: Swahn, B | [[Category: Swahn, B M.]] | ||
[[Category: Viklund, J.]] | [[Category: Viklund, J.]] | ||
[[Category: Weigelt, T.]] | [[Category: Weigelt, T.]] | ||
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[[Category: kinase inhibitor]] | [[Category: kinase inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:17 2008'' | ||
