2b2s: Difference between revisions

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==Overview==

The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.

The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.

==About this Structure==

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[[Category: Fita, I.]]

[[Category: Ivancich, A.]]

[[Category: Loewen, P.C.]]

[[Category: Loewen, P C.]]

[[Category: Singh, R.]]

[[Category: Switala, J.]]

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[[Category: oxoferryl species]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jan 29 18~~:15:12 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:33 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.
+The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
 ==About this Structure==
@@ Line 18: / Line 18: @@
 [[Category: Fita, I.]]
 [[Category: Ivancich, A.]]
-[[Category: Loewen, P.C.]]
+[[Category: Loewen, P C.]]
 [[Category: Singh, R.]]
 [[Category: Switala, J.]]
@@ Line 30: / Line 30: @@
 [[Category: oxoferryl species]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:15:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:33 2008''