2b3e: Difference between revisions
New page: left|200px<br /><applet load="2b3e" size="350" color="white" frame="true" align="right" spinBox="true" caption="2b3e, resolution 1.36Å" /> '''Crystal structure of... |
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==Overview== | ==Overview== | ||
The crystal structure of the DNA minor groove biphenyl benzimidazole | The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined. | ||
==About this Structure== | ==About this Structure== | ||
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Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16263285 16263285] | Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16263285 16263285] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Campbell, N | [[Category: Campbell, N H.]] | ||
[[Category: Evans, D | [[Category: Evans, D A.]] | ||
[[Category: Lee, M | [[Category: Lee, M P.]] | ||
[[Category: Neidle, S.]] | [[Category: Neidle, S.]] | ||
[[Category: Parkinson, G | [[Category: Parkinson, G N.]] | ||
[[Category: DBN]] | [[Category: DBN]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: nucleic acids]] | [[Category: nucleic acids]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:42 2008'' | ||
Revision as of 14:33, 21 February 2008
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Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.
Overview
The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.
About this Structure
2B3E is a Protein complex structure of sequences from [1] with MG and DBN as ligands. Full crystallographic information is available from OCA.
Reference
Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:16263285
Page seeded by OCA on Thu Feb 21 16:33:42 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Protein complex
- Campbell, N H.
- Evans, D A.
- Lee, M P.
- Neidle, S.
- Parkinson, G N.
- DBN
- MG
- A2t2
- Crystal structure of b-dna
- Db819
- Dickerson and drew dodecamer
- Dna
- Dna hydration.
- Dna minor
- Dna minor groove-ligand complex
- Dna-drug complex
- Double helix
- Groove binder
- Hydrated magnesium
- Magnesium-water complex
- Minor groove
- Nucleic acids
