2b8l: Difference between revisions
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==Overview== | ==Overview== | ||
We have synthesized and evaluated a series of conformationally biased P3 | We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kuo, L.]] | [[Category: Kuo, L.]] | ||
[[Category: Munshi, S | [[Category: Munshi, S K.]] | ||
[[Category: 5HA]] | [[Category: 5HA]] | ||
[[Category: aspartyl protease]] | [[Category: aspartyl protease]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:35:13 2008'' | ||
